[Ru(bpy)₂(bppp)]^2 + binds two different forms of the human telomeric G-quadruplex structure

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• 作者：Shuo Shi ; Chunyan Lv ; Xing Gao ; Juan Zhao ; Junliang Yao ; Wenliang Sun ; Hailing Huang ; Tianming Yao ; Liangnian Ji
• 关键词：Ruthenium complexes ; G-quadruplex ; Stabilization ; FID ; Molecular docking
• 刊名：Inorganic Chemistry Communications
• 出版年：2012
• 出版时间：October, 2012
• 年：2012
• 卷：24
• 期：Complete
• 页码：212-215
• 全文大小：784 K

文摘

A new complex [Ru(bpy)₂(bppp)]^2 + (bpy = 2,2¡ä-bipyridine, bppp = 12-bromo-pyrido[2¡ä,3¡ä:5,6]pyrazino[2,3-f][1,10]phenanthroline) has been synthesized and characterized. The interaction of the title complex with two different forms of the human telomeric G-quadruplexes DNA was explored by means of CD spectroscopy, CD melting, fluorescent intercalator displacement (FID) and molecular docking studies. Results indicated that [Ru(bpy)₂(bppp)]^2 + not only induce formation of antiparallel G-quadruplex structure in the absence of metal cations, but also have the ability to stabilize the G-quadruplexes DNA.