SOX7 is associated with the suppression of human glioma by HMG-box dependent regulation of Wnt/β-catenin signaling
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- 作者：Tianshu Zhaoa ; 1 ; Hui Yangb ; 1 ; Yu Tianc ; Qing Xied ; Yun Lub ; Yu Wangb ; Ning Sue ; Baijing Donga ; Xian Liua ; Ce Wanga ; Chuanlu Jiangc ; jiangchuanlusox@163.com" class="auth_mail" title="E-mail the corresponding author ; Xiaoqian Liua ; liuxiaoqiansox@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Glioma ; SOX7 ; Wnt/β-catenin ; Tumor suppressor
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 May 2016
- 年：2016
- 卷：375
- 期：1
- 页码：100-107
- 全文大小：2018 K
文摘
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Loss of SOX7 expression was found in human glioma.
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SOX7 related Wnt/β-catenin signaling upregulation plays an important role in glioma progression.
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HMG-box is a key domain of SOX7 for negatively regulating the Wnt/β-catenin signaling pathway.