Probing ischemic tissue fate with BOLD fMRI of brief oxygen challenge
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- 作者：Qiang ; Shen ; Shiliang ; Huang ; Fang ; Du ; Timothy Q. ; Duong ; ; duongt@uthscsa.edu
- 关键词：MRI ; Perfusion ; Diffusion ; Oxygen inhalation ; Penumbra
- 刊名：Brain Research
- 出版年：2011
- 出版时间：24 November 2011
- 年：2011
- 卷：1425
- 期：Complete
- 页码：132-141
- 全文大小：1356 K
文摘
It has been recently shown that at-risk tissue exhibits exaggerated T2?/sup>-weighted MRI signal increases during transient oxygen challenge (OC), suggesting that the tissue is still metabolically active. This study further characterized the effects of transient OC on T2?/sup>-weighted MRI in permanent focal stroke rats (N = 8) using additional quantitative measures. The major findings were: i) the ischemic core cluster showed no significant response, whereas the mismatch cluster showed markedly higher percent changes relative to normal tissue in the acute phase. ii) Many of the mismatch pixels showed exaggerated OC responses which became hyperintense on T2-weighted MRI at 24 h. The area with exaggerated OC responses was larger than the mismatch, suggesting that some tissue with reduced diffusion were potentially at risk. iii) Basal T2?/sup>-weighted intensities on the perfusion¨Cdiffusion contourplot were high in normal tissue and low in the core, with a sharp transition in the mismatch. iv) OC-induced changes on the perfusion¨Cdiffusion contourplot dropped as perfusion and diffusion values fell below their respective viability thresholds. v) Basal T1 increased slightly in the ischemic core (P < 0.05). OC decreased T1 in normal (P < 0.05) but not in mismatch and core pixels. vi) OC decreased CBF in normal (P < 0.05) but not in mismatch and core pixels. T2?/sup>-weighted MRI of OC has the potential to offer unique clinically relevant data.