Levels of
allergen-specific IgE
and IgG
antibodies were determined in serum s
amples from 60
atopic
and 11 norm
al dogs by me
ans of commerci
ally
av
ail
able
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ache/Mi
amiIm
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and
a p
anel of 33
allergens. In the
atopic popul
ation, IgE
antibodies were most commonly identified with
a specificity for
Dermatophagoides farinae (78·3 per cent of
affected dogs),
D pteronyssinus (61·6 per cent),
mould mix (25 per cent)
and house dust (19 per cent), where
as the most frequently detected IgG
antibodies h
ad
a specificity for
D farinae (38·3 per cent),
D pteronyssinus (33·3 per cent),
mould mix (33·3 per cent), insect mix (16·6 per cent)
and me
adow fescue (16·6 per cent). The IgG subcl
ass profile of
allergen-specific
antibodies w
as determined for five represent
ative
allergens from the p
anel. The IgG response to
D farinae and
D pteronyssinus w
as domin
ated by IgG4
antibodies,
although lower levels of IgG2,
and IgG3
and IgGl
D pteronyssinus antibodies were
also detected. The IgG response to
Timothy gr
ass w
as predomin
antly within the IgGI
and IgG4 subcl
asses. IgG subcl
ass selection in the response to
mould mix
and insect mix w
as bro
ader, with rel
atively low level re
actions from
all four subcl
asses. The d
at
a suggest
a degree of IgG subcl
ass restriction in the Immor
al immune response of c
anine
atopy which m
ay be dependent upon the n
ature of the
allergen.