Alteration of behavior and monoamine levels attributable to Lactobacillus plantarum PS128 in germ-free mice
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- 作者：Wei-Hsien Liua ; Hsiao-Li Chuangb ; Yen-Te Huangb ; Chien-Chen Wua ; Geng-Ting Choua ; Sabrina Wangd ; sabrina@ym.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Ying-Chieh Tsaia ; c ; tsaiyc@ym.edu.tw" class="auth_mail" title="E-mail the corresponding author
- 关键词：ALT ; alanine aminotransferase ; CPK ; creatine phosphokinase ; CREA ; creatinine ; DA ; dopamine ; EPM ; elevated plus maze ; FST ; forced swim test ; GBA ; gut&ndash ; brain axis ; GF ; germ-free ; HPLC&ndash ; ECD ; high-performance liquid chromatography with electrochemical detection system ; MRS ; Man Rogosa Sharpe ; NA ; noradrenaline ; OFT ; open field test ; SPF ; specific pathogen-free ; TG ; triacylglycerol
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：1 February 2016
- 年：2016
- 卷：298
- 期：part_PB
- 页码：202-209
- 全文大小：1741 K
文摘
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Both live and heat-killed PS128 showed no obvious toxic effects to the germ-free (GF) mice.
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Live PS128 increased locomotor activity of the GF mice.
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Live PS128 reduced anxiety-like behavior of the GF mice in the elevated plus maze.
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Live PS128 increased both dopamine and serotonin level in the striatum.