Identification and characterization of the toll-like receptor 8 gene in the Chinese raccoon dog (Nyctereutes procyonoides)
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- 作者：Yong Yanga ; b ; 1 ; Mingwei Tongb ; 1 ; Li Yib ; 1 ; Yuening Chengb ; Miao Zhangb ; Zhigang Caob ; Jianke Wangb ; Peng Linb ; Shipeng Chengb ; tcs_csp@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：TLR8 ; Nyctereutes procyonoides ; Sequence analysis ; Gene expression
- 刊名：Immunology Letters
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：178
- 期：Complete
- 页码：50-60
- 全文大小：4888 K
文摘
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TLR8 gene was for the first time cloned and characterized from Nyctereutesprocyonoides.
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Results indicate RdTLR8 transcripts distributed with higher levels in PBMCs and spleen.
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HEK293 cells transfected with RdTLR8 and NF-κB-luciferase containing plasmids responded to TLR8 agonists 3M-002.
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RdTLR8 and IFN-α were significantly up-regulated after canine distemper virus infection and TLR8 agonists 3M-002 stimulation.