¦Á-Tocopherol (vitamin E) stimulates cyclic AMP production in human peripheral mononuclear cells and alters immune function

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• 作者：Sonemany Salinthone ; Amelia R. Kerns ; Vivian Tsang ; Daniel W. Carr
• 关键词：cAMP ; 3&prime ; 5&prime ; cyclic adenosine monophosphate ; IL ; interleukin ; RANTES ; Normal T cell Expressed and Secreted ; PBMC ; peripheral blood mononuclear cell ; GPCR ; G-protein coupled receptor ; AC ; adenylyl cyclase ; PKA ; protein kinase A ; NK ; natural kille
• 刊名：Molecular Immunology
• 出版年：2013
• 出版时间：March, 2013
• 年：2013
• 卷：53
• 期：3
• 页码：173-178
• 全文大小：345 K

文摘

¦Á-Tocopherol, the most biologically active member of the vitamin E family of fat soluble compounds, exhibits both antioxidant and anti-inflammatory properties. However, its mechanisms of action are not fully understood. Here, we show that, unlike other antioxidants, ¦Á-tocopherol stimulates the production of cyclic adenosine monophosphate (cAMP). Inhibitor studies demonstrate that the prostaglandin EP2 and EP4 receptors and adenylyl cyclases mediate the effects of ¦Á-tocopherol on cAMP production. Additionally, we show that ¦Á-tocopherol attenuates pro-inflammatory cytokine and chemokine production. This study provides novel evidence that ¦Á-tocopherol stimulates cAMP signaling, suggesting a mechanism of action for the immunomodulatory effects of vitamin E.