Alteration of ¦Á-tocopherol-associated protein (TAP) expression in human breast epithelial cells during breast cancer development

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• 作者：Ka-Wai Tam^a ; ^b ; ^c ; Chi-Tang Ho^d ; Wen-Jui Lee^e ; ^f ; Shih-Hsin Tu^c ; ^g ; Ching-Shui Huang^c ; ^g ; Ching-Shyang Chen^b ; ^h ; ⁱ ; Chia-Hwa Lee^f ; ^j ; ^{chlee@tmu.edu.tw} ; Chih-Hsiung Wu^b ; ^c ; ^j ; ^k ; ^{chwu@tmu.edu.tw} ; Yuan-Soon Ho^f ; ^j ; ^{hoyuansn@tmu.edu.tw}
• 关键词：Breast cancer ; ¦Á-Tocopherol-associated protein ; Vitamin E ; Her2/neu receptor
• 刊名：Food Chemistry
• 出版年：2013
• 出版时间：1 June, 2013
• 年：2013
• 卷：138
• 期：2-3
• 页码：1015-1021
• 全文大小：566 K

文摘

Breast cancer is the most common malignancy among women and has an age-specific incidence profile. Over the last decade, many studies have demonstrated the anticancer activity of ¦Á-tocopherol, the main and most active form of natural vitamin E. ¦Á-Tocopherol-associated protein (TAP) was found to be one of the major ¦Á-tocopherol binding proteins in human serum and in liver, brain, and prostate tissues. In this study, we found that reduced TAP expression was significantly correlated with Her2/neu receptor expression, breast cancer stage and nodal stage in paired normal and cancerous breast tissue samples from 93 patients using real-time PCR analysis. A cell viability assay showed that ¦Á-tocopheryl succinate (¦Á-TOS), a synthetic derivative of ¦Á-tocopherol, enhanced the cells¡¯ sensitivity to doxorubicin and resulted in a reduction in cell viability in breast cancers. Taken together, these data suggest that the use of vitamin E or its analogue as a dietary supplement may be beneficial for the treatment of cancer.