UHPLC/Q-TOFMS-based plasma metabolomics of polycystic ovary syndrome patients with and without insulin resistance
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- 作者：Ya-Xiao Chena ; 1 ; Xiao-Jing Zhangb ; 1 ; Jia Huanga ; Shu-Jun Zhoub ; Fang Liub ; Lin-Lin Jianga ; Meiwan Chenb ; Wan Jian-Bob ; jbwan@umac.mo" class="auth_mail" title="E-mail the corresponding author ; wjbcpu@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Dong-Zi Yanga ; yangdz@mail.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Polycystic ovary syndrome ; Insulin resistance ; Metabolomics ; UHPLC/Q-TOFMS
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：20 March 2016
- 年：2016
- 卷：121
- 期：Complete
- 页码：141-150
- 全文大小：2574 K
文摘
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Potential diagnostic biomarkers of PCOS with/without IR were found via metabolomics.
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Decanoylcarnitine is identified as potential diagnostic biomarker of PCOS without IR.
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Trilauric glyceride is a possible biomarker of PCOS with IR complication.
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The fatty acid disorder participates in PCOS and IR complications.