Analysis of the structure and function of EMRE in a yeast expression system
详细信息 查看全文
- 作者：Takenori Yamamotoa ; b ; tyamamo@genome.tokushima-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Ryohei Yamagoshia ; b ; Kazuki Haradaa ; b ; Mayu Kawanoa ; b ; Naoki Minamia ; b ; Yusuke Idoa ; b ; Kana Kuwaharaa ; b ; Atsushi Fujitaa ; b ; Mizune Ozonoa ; b ; Akira Watanabea ; b ; Akiko Yamadac ; Hiroshi Teradad ; Yasuo Shinoharaa ; b ; yshinoha@genome.tokushima-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：AAC2 ; ADP/ATP carrier 2 ; CPR3 ; cyclophilin C ; EGFP ; enhanced green fluorescent protein ; EMRE ; the essential MCU regulator ; MCU ; mitochondrial calcium uniporter ; MCUR1 ; mitochondrial calcium uniporter regulator 1 ; MICU1 ; mitochondrial calcium uptake 1 ; MTS ; mitochondrion-targeting signal
- 刊名：Biochimica et Biophysica Acta (BBA) - Bioenergetics
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：1857
- 期：6
- 页码：831-839
- 全文大小：1625 K
文摘
- •
Properties of mammalian calcium uniporter could be precisely reconstituted in yeast.
- •
EMRE's topology in mitochondrial inner membrane was revealed.
- •
EMRE closely interacted with MCU on both sides of the inner membrane.
- •
The interaction of EMRE with MCU was critical for Ca2 + uptake.