Expression quantitative trait analysis reveals fine germline transcript regulation in mouse lung tumors
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- 作者：Chiara E. Cotroneoa ; 1 ; 2 ; Alice Dassanoa ; 1 ; Francesca Colomboa ; Angela Pettinicchioa ; Daniele Lecisb ; Matteo Dugob ; Loris De Ceccob ; Tommaso A. Dragania ; tommaso.dragani@istitutotumori.mi.it" class="auth_mail" title="E-mail the corresponding author ; Giacomo Manentia
- 关键词：Animal models ; Expression quantitative trait loci ; Gene expression ; Lung cancer ; Transcriptome ; Pas1
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：375
- 期：2
- 页码：221-230
- 全文大小：3634 K
文摘
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Gene expression modulates cellular functions in tumors.
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Pas1 locus is the major modulator of lung tumorigenesis in mice.
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Pas1 acts as a major regulator of transcription in lung tumors.
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Components or targets of the Ras–Erk and Pi3k–Akt signaling pathways are involved.