Recombinant protein of Haemonchus contortus 14-3-3 isoform 2 (rHcftt-2) decreased the production of IL-4 and suppressed the proliferation of goat PBMCs in vitro

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• 作者：Javaid Ali Gadahi¹ ; ^{drgadahi@yahoo.com} ; Muhammad Ehsan¹ ; ^{mehsan124@gmail.com} ; Shuai Wang ^{tongbaiws1003@163.com} ; ZhenChao Zhang ^{zhangzhenchao525@163.com} ; Yujian Wang ^{453425665@qq.com} ; RuoFeng Yan ^{yanruofeng@njau.edu.cn} ; XiaoKai Song ^{songxiaokai@njau.edu.cn} ; LiXin Xu ^{xulixin@njau.edu.cn} ; XiangRui Li ; ^{lixiangrui@njau.edu.cn}
• 关键词：Haemonchus contortus ; 14-3-3 protein ; PBMCs ; Goat ; Cytokine
• 刊名：Experimental Parasitology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：171
• 期：Complete
• 页码：57-66
• 全文大小：2138 K
• 卷排序：171

文摘

14-3-3 proteins assumed to be released into the host–parasite interface. The rHcftt-2 was bound to the PBMC surface. IL10, IL-17, IFN-γ and cell migration of PBMCs were induced by rHCftt-2. IL-4, NO production, cell proliferation of PBMCs were suppressed by rHCftt-2. Hcftt-2 was played important suppressive regulatory effects on the goat PBMCs.