Effects of Environmental Exposures on Fetal and Childhood Growth Trajectories

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• 作者：Tongzhang Zheng ; PhD ; MD^&lowast ; ; ^{tongzhang_zheng@brown.edu" class="auth_mail" title="E-mail the corresponding author} ; Jie Zhang ; MPH Candidate^&lowast ; ; Kathryn Sommer ; BSc Candidate^&dagger ; ; Bryan A. Bassig ; PhD^&Dagger ; ; Xichi Zhang ; BSc Candidate^§ ; ; Jospeh Braun ; PhD^&lowast ; ; Shuangqing Xu ; MD^‖ ; Peter Boyle ; PhD^¶ ; ; Bin Zhang ; MD^# ; Kunchong Shi ; MD^&lowast ; ; Stephen Buka ; ScD^&lowast ; ; Siming Liu ; PhD^&lowast ; ; Yuanyuan Li ; PhD^&lowast ; ; ^‖ ; Zengmin Qian ; PhD^&lowast ; &lowast ; ; Min Dai ; PhD^&dagger ; &dagger ; ; Megan Romano ; PhD^&lowast ; ; Aifen Zou ; MD^# ; Karl Kelsey ; MD^&lowast ;
• 关键词：prenatal exposure ; environmental pollutants ; fetal growths ; adverse birth outcomes ; low birth weight ; catch-up growth ; child development
• 刊名：Annals of Global Health
• 出版年：2016
• 出版时间：January-February 2016
• 年：2016
• 卷：82
• 期：1
• 页码：41-99
• 全文大小：1111 K

文摘

Delayed fetal growth and adverse birth outcomes are some of the greatest public health threats to this generation of children worldwide because these conditions are major determinants of mortality, morbidity, and disability in infancy and childhood and are also associated with diseases in adult life. A number of studies have investigated the impacts of a range of environmental conditions during pregnancy (including air pollution, endocrine disruptors, persistent organic pollutants, heavy metals) on fetal and child development. The results, while provocative, have been largely inconsistent. This review summarizes up to date epidemiologic studies linking major environmental pollutants to fetal and child development and suggested future directions for further investigation.