Investigation of DNA binding, DNA photocleavage, topoisomerase I inhibition and antioxidant activities of water soluble titanium(IV) phthalocyanine compounds
详细信息 查看全文
- 作者：Arzu Ö ; zela ; arzuozenozel@ktu.edu.tr" class="auth_mail" title="E-mail the corresponding author ; Burak Baruta ; Ü ; mit Demirbaşb ; Zekeriya Biyiklioglub
- 关键词：Phthalocyanines ; DNA-binding ; DNA-cleavage ; Topoisomerase I inhibition ; Antioxidant
- 刊名：Journal of Photochemistry and Photobiology B: Biology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：157
- 期：Complete
- 页码：32-38
- 全文大小：815 K
文摘
- •
The Kb of Pc compounds was 3.75 × 104, 2.3 × 104 and 4.57 × 104.
- •
Pc compounds exhibited significant inhibitory effects against topoisomerase I.
- •
These phthalocyanine compounds bind to CT-DNA via minor groove binding.
- •
Pc3 compound had the highest DNA binding affinity and DNA cleavage activity.