Long-term continuous allopregnanolone elevation causes memory decline and hippocampus shrinkage, in female wild-type B6 mice
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- 作者：Sara K.S. Bengtssona ; sara.bengtsson@obgyn.umu.se" class="auth_mail" title="E-mail the corresponding author ; Maja Johanssona ; b ; Torbjö ; rn Bä ; ckströ ; ma
- 关键词：Allopregnanolone ; Memory and learning ; Chronic stress ; Mild cognitive impairment ; Dementia ; Brain tissue weight ; GABA ; Wild-type mice ; C57BL/6J mice
- 刊名：Hormones and Behavior
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：78
- 期：Complete
- 页码：160-167
- 全文大小：587 K
文摘
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The long-term continuous allopregnanolone treatment led to a steroid elevation similar to that of chronic stress.
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The continuous steroid elevation caused learning and memory impairment and reduced hippocampus weight in wild-type mice.
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Correlation between learning and memory function and hippocampus weight was lost after allopregnanolone elevation.
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Continuous allopregnanolone elevation may be an important link in the mechanism behind stress-induced cognitive decline.