Synthesis and cytotoxic activity evaluation of 2,3-thiazolidin-4-one derivatives on human breast cancer cell lines
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- 作者：Marina Sala ; Adele Chimento ; Carmela Saturnino ; Isabel M. Gomez-Monterrey ; Simona Musella ; Alessia Bertamino ; Ciro Milite ; Maria Stefania Sinicropi ; Anna Caruso ; Rosa Sirianni ; Paolo Tortorella ; Ettore Novellino ; Pietro Campiglia ; Vincenzo Pezzi
- 关键词：Resveratrol analogs anticancer drugs ; 2 ; 3-Thiazolidin-4-one derivatives ; Polyphenol ; Breast cancer cells ; MCF-7 ; SKBR3
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2013
- 出版时间：1 September, 2013
- 年：2013
- 卷：23
- 期：17
- 页码：4990-4995
- 全文大小：1767 K
文摘
It is well known that resveratrol (RSV) displayed cancer-preventing and anticancer properties but its clinical application is limited because of a low bioavailability and a rapid clearance from the circulation. Aim of this work was to synthesize pharmacologically active resveratrol analogs with an enhanced structural rigidity and bioavailability. In particular, we have synthesized a library of 2,3-thiazolidin-4-one derivatives in which a thiazolidinone nucleus connects two aromatic rings. Some of these compounds showed strong inhibitory effects on breast cancer cell growth. Our results indicate that some of thiazolidin-based resveratrol derivatives may become a new potent alternative tool for the treatment of human breast cancer.