The Transcription Factor NF-ATc1 Regulates Lymphocyte Proliferation and Th2 Cytokine Production

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• 作者：Hiroki Yoshida ; Hiroshi Nishina ; Hiroaki Takimoto ; Luc E. M. Marengè ; re ; Andrew C. Wakeham ; Denis Bouchard ; Young-Yun Kong ; Toshiaki Ohteki ; Arda Shahinian ; Martin Bachmann ; Pamela S. Ohashi ; Josef M. Penninger ; Gerald R. Crabtree ; Tak W. Mak
• 刊名：Immunity
• 出版年：1998
• 出版时间：1 January 1998
• 年：1998
• 卷：8
• 期：1
• 页码：115-124
• 全文大小：247 K

文摘

NF-ATc1 is a member of a family of genes that encodes the cytoplasmic component of the nuclear factor of activated T cells (NF-AT). In activated T cells, nuclear NF-AT binds to the promoter regions of multiple cytokine genes and induces their transcription. The role of NF-ATc1 was investigated in recombination activating gene-1 (RAG-1)–deficient blastocyst complementation assays using homozygous NF-ATc1^−/− mutant ES cell lines. NF-ATc1^−/−/RAG-1^−/− chimeric mice showed reduced numbers of thymocytes and impaired proliferation of peripheral lymphocytes, but normal production of IL-2. Induction in vitro of Th2 responses, as demonstrated by a decrease in IL-4 and IL-6 production, was impaired in mutant T cells. These data indicate that NF-ATc1 plays roles in the development of T lymphocytes and in the differentiation of the Th2 response.