Anti-proliferative effect of the abl tyrosine kinase inhibitor STI571 on the P-glycoprotein positive K562/ADM cell line

详细信息    查看全文

• 作者：Kotaki ; Mitsuko ; Motoji ; Toshiko ; Takanashi ; Minoko ; Wang ; Yan-Hua ; Mizoguchi ; Hideaki
• 关键词：STI571 ; P-glycoprotein ; Multidrug resistance ; MS-209 ; K562 cell line
• 刊名：Cancer Letters
• 出版年：2003
• 出版时间：September 10, 2003
• 年：2003
• 卷：199
• 期：1
• 页码：61-68
• 全文大小：250 K

文摘

STI571, an abl tyrosine kinase inhibitor, is less effective in chronic myelogenous leukemia (CML) patients in the accelerated phase and in blastic crisis. We addressed whether STI571 is effective for the CML blastic crisis cell line K562 and the P-glycoprotein (P-gp) positive, multidrug resistance cell line K562/ADM. The present results demonstrate that P-gp positive K562/ADM cells were more resistant than K562 cells to the anti-proliferative and apoptotic effect of STI571, but the co-addition of a P-gp modulator augmented the sensitivity of K562/ADM cells to STI571. For patients in CML blastic crisis, simultaneous use of a P-gp modulator may increase the efficacy of STI571.