Pyothorax-associated lymphoma: A case showing transition from T-cell-rich polymorphic lesion to diffuse large B-cell lymphoma

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• 作者：Tomoko Yamamoto ; Akihiro Masuda ; Tatsuo Sawada ; Toshio Nishikawa ; Kentaro Yoshinaga ; Hiroshi Kazama ; Toshiko Motoji ; Naoya Nakamura ; Makio Kobayashi
• 关键词：Pyothorax-associated lymphoma ; Epstein– ; Barr virus ; T-cell rich ; Polymorphic
• 刊名：Pathology - Research and Practice
• 出版年：2007
• 出版时间：30 August 2007
• 年：2007
• 卷：203
• 期：8
• 页码：605-611
• 全文大小：1304 K

文摘

Pyothorax-associated lymphoma was found in a man who had a history of collapse therapy for pulmonary tuberculosis about 50 years ago. An autopsy specimen revealed histology of diffuse large B-cell lymphoma with latency III Epstein–Barr virus (EBV) infection. However, an open biopsy 2 years and 7 months before death showed a polymorphic appearance with abundant T-lymphocytes. Most of the EBV-infected atypical lymphocytes did not express either B- or T-cell markers as far as examined in the paraffin-embedded biopsy specimen, and rearrangements of immunoglobulin and T-cell receptors were not found. It seemed difficult to diagnose a B-cell lymphoma at the time of biopsy. However, retrospectively considered, if a phenotype of EBV-infected atypical lymphocytes is uncertain in cases showing polymorphic appearance, it might be better to consider the future evolution to overt B-cell lymphoma. Since pyothorax-associated lymphoma shows latency III infection of EBV, at least the immunohistochemistry of EBNA-2 and LMP-1 seems helpful for the diagnosis to prove which cells are infected by EBV.