In vivo anticancer activity of maesopsin 4-O-β-glucoside isolated from leaves of Artocarpus tonkinensis A. Chev. Ex Gagnep

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• 作者：Trinh Thi Thuy¹ ; ^{drthuy2001@yahoo.de" class="auth_mail" title="E-mail the corresponding author} ; ^{thuy@ich.vast.vn" class="auth_mail" title="E-mail the corresponding author} ; Dao Duc Thien¹ ; Tran Quang Hung¹ ; Nguyen Thanh Tam¹ ; Nguyen Thi Hoang Anh¹ ; Nguyen Thi Nga² ; Nguyen Thi Cuc² ; Le Phuong Mai³ ; Tran Van Sung¹ ; Domenico V. Delfino⁴ ; Do Thi Thao² ; ^{thaodo@ibt.ac.vn" class="auth_mail" title="E-mail the corresponding author} ; ^{thaodo74@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Artocarpus tonkinensis ; BALB/c ; Hematological parameters ; Lewis lung carcinoma ; Maesopsin 4-O-β-glucoside
• 刊名：Asian Pacific Journal of Tropical Medicine
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：9
• 期：4
• 页码：351-356
• 全文大小：510 K

文摘

To investigate the antitumor effect of maesopsin 4-O-β-glucoside (TAT2) isolated from the leaves of Artocarpus tonkinensis (A. tonkinensis) A. Chev. ex Gagnep.

Methods

The antitumor activity of TAT2 was evaluated in Lewis lung carcinoma (LLC) tumor-bearing mice. BALB/c mice had tumors induced by implantation with 2 × 10⁶ LLC cells into the subcutaneous right posterior flank. Tumor-bearing mice were treated orally with a range of doses of TAT2 and a standard drug, doxorubicin. Animals were observed for tumor growth and mortality rate. Blood was collected to determine hematological and biochemical parameters.

Results

TAT2 was isolated from an ethanolic extract of A. tonkinensis leaves. Its structure was determined by MS and NMR spectroscopy, and identified as TAT2. The compound did not show acute toxicity at the highest dose tested (2 000 mg/kg body weight). TAT2 exhibited antitumor activity by decreasing tumor growth, increasing the survival rate, and ameliorating some hematological and biochemical parameters at doses of 100 and 200 mg/kg body weight (P < 0.05).

Conclusions

These results indicate that TAT2 possesses clear antitumor activity. Due to its bioavailability and low toxicity, and the fact that it could be isolated in a large scale from A. tonkinensis leaves, the compound shows promise as a potential anticancer drug.