Resveratrol via sirtuin-1 downregulates RE1-silencing transcription factor (REST) expression preventing PCB-95-induced neuronal cell death
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- 作者：Natascia Guidaa ; 1 ; Giusy Laudatib ; 1 ; Serenella Anzilottia ; Agnese Secondob ; Paolo Montuoric ; Gianfranco Di Renzob ; Lorella M.T. Canzonierob ; d ; Luigi Formisanob ; d ; cformisa@unisannio.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：AP-1 ; activator protein 1 ; PCB-NDL ; polychlorinated biphenyl non-dioxin-like ; RSV ; resveratrol (3 ; 5 ; 4&prime ; -trihydroxy-trans-stilbene) ; EX-527 ; 6-chloro-2 ; 3 ; 4 ; 9-tetrahydro-1H-carbazole-1-carboxamide ; SIRT1 ; sirtuin 1 ; MS ; oligodeoxynucleotide missense ; AS ; oligodeoxynucleotide antisense ; ChIP ; chromatin immunoprecipitation ; LDH ; lactate dehydrogenase ; REST ; repressor element-1 silencing transcription factor ; DCFH-DA ; 2&prime ; 7&prime ; -dichlorodihydrofluorescein diacetate
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2015
- 出版时间：1 November 2015
- 年：2015
- 卷：288
- 期：3
- 页码：387-398
- 全文大小：1739 K
文摘
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10">Resveratrol via SIRT1/c-Jun downregulates REST mRNA and protein in SH-SY5Y cells.
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15">Non-dioxin-like (NDL) PCB-95 is cytotoxic to SH-SY5Y cells and cortical neurons.
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PCB-95-induced cytotoxicity is mediated by REST.
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PCB-95-induced cell death is inhibited by resveratrol.