Selective repression of gene expression in neuropathic pain by the neuron-restrictive silencing factor/repressor element-1 silencing transcription (NRSF/REST)
详细信息 查看全文
- 作者：Dianna E. Willisa ; b ; Meng Wanga ; Elizabeth Browna ; Lilah Fonesa ; John W. Cavea ; b ; joc2042@med.cornell.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ENCODE ; encyclopedia of DNA elements ; HDAC ; histone deacetylase ; MeCP2 ; methyl CpG binding protein 2 ; miRNA ; micro-RNA ; NRSF ; neuron-restrictive silencing factor ; REST ; repressor element-1 silencing transcription
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：20 June 2016
- 年：2016
- 卷：625
- 期：Complete
- 页码：20-25
- 全文大小：981 K
文摘
- •
Nerve injury or disease can cause persistent nociceptive hypersensitivity.
- •
10">Transition is accompanied by changes in the transcriptome of PNS and CNS circuits.
- •
15">Neuropathic pain is associated with increased NRSF expression.
- •
NRSF represses a subset of its developmental targets after injury.