REST levels affect the functional expression of voltage dependent calcium channels and the migratory activity in immortalized GnRH neurons
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- 作者：Susanna Antoniottia ; b ; Federico Alessandro Ruffinattia ; 1 ; Simona Torrianoa ; 2 ; Anna Luganinia ; Rosalba D&rsquo ; Alessandroc ; Davide Lovisoloa ; b ; d ; davide.lovisolo@unito.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：REST/NRSF ; repressor element-1 silencing transcription factor/neuron restrictive silencer factor ; VDCCs ; voltage dependent calcium channels ; GnRH ; gonadotropin hormone-releasing hormone
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：26 August 2016
- 年：2016
- 卷：629
- 期：Complete
- 页码：19-25
- 全文大小：1323 K
文摘
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We downregulated REST transcription factor in neuronal GN11 cell line by silencing.
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10">994-D4 clone, expressing low REST levels, showed a reduced migratory potential.
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15">REST silencing increased expression of functional voltage-dependent Ca2+ channels.
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Enhancement of depolarization-induced calcium signals is dependent on P/Q channels.