Growth hormone regulates the expression of UCP2 in myocytes
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- 作者：Kumi Futawakaa ; kumif@mukogawa-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Tetsuya Tagamib ; Yuki Fukudaa ; Rie Koyamaa ; Ayaka Nushidaa ; Syoko Nezua ; Miyuki Imamotob ; Masato Kasaharab ; Kenji Moriyamaa ; b ; c
- 关键词：AGHD ; adult growth hormone deficiency ; GH ; growth hormone ; GHR ; growth hormone receptor ; IGF-I ; insulin-like growth factor-I ; JAK ; Janus kinase ; MAPK ; mitogen-activated protein kinase ; PI3K ; phosphoinositide-3 kinase ; STAT ; signal transduction and activator of transcription ; UCP ; uncoupling protein
- 刊名：Growth Hormone & IGF Research
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：29
- 期：Complete
- 页码：57-62
- 全文大小：887 K
文摘
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Signaling pathways activated by growth hormone (GH) during energy metabolism analyzed.
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10">GH found to directly enhance expression of UCP2, key protein in energy metabolism.
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15">Effect mediated via STAT5B, signal transducer downstream of GH.
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Results may aid development of drugs for treatment of AGHD and obesity.