Transferrin receptor regulates pancreatic cancer growth by modulating mitochondrial respiration and ROS generation
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- 作者：Seung Min Jeonga ; b ; smjeong@catholic.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Sunsook Hwangc ; Rho Hyun Seongc
- 关键词：Transferrin receptor ; Mitochondrial respiration ; ROS ; PDAC
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：11 March 2016
- 年：2016
- 卷：471
- 期：3
- 页码：373-379
- 全文大小：938 K
文摘
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Pancreatic ductal adenocarcinoma (PDAC) exhibits an elevated transferrin receptor (TfR1) expression in comparison with non-transformed pancreatic cells.
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TfR1 is required for PDAC growth by regulating mitochondrial respiration and ROS production.
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TfR1 functions as a determinant of cell viability to oxidative stress in PDAC cells.