Contributions of transferrin to acute inflammation in the goldfish, C. auratus

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• 作者：M.J. Trites^a ; D.R. Barreda^a ; ^b ; ^{Dan.Barreda@ualberta.ca}
• 关键词：Transferrin ; Acute inflammation ; Teleost immunity ; Leukocyte responses ; Evolution
• 刊名：Developmental & Comparative Immunology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：67
• 期：Complete
• 页码：300-309
• 全文大小：1669 K
• 卷排序：67

文摘

First evidence of endogenously produced transferrin cleavage products in vivo. Both macrophages and neutrophils contributed to transferrin cleavage. Macrophages, but not neutrophils, displayed inducible transferrin gene expression. Transferrin cleavage products were generated only in pathogen induced inflammation. Differential transferrin cleavage observed depending on pathogen stimuli.