Interaction of imatinib mesylate with human serum transferrin: The comparative spectroscopic studies
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文摘
The interactions between all states of transferrin and imatinib mesylate have been studied. The binding constants of the drug to the proteins are comparable to other drugs. The common metal ions caused the increase of apo-Tf-Imt binding constant. The imatinib mesylate does not produce significant changes in the secondary structure of the proteins. The apo-Tf-Imt system is unstable under physiological conditions.

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