刊名:Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
出版年:2017
出版时间:15 February 2017
年:2017
卷:173
期:Complete
页码:468-475
全文大小:849 K
卷排序:173
文摘
The interactions between all states of transferrin and imatinib mesylate have been studied. The binding constants of the drug to the proteins are comparable to other drugs. The common metal ions caused the increase of apo-Tf-Imt binding constant. The imatinib mesylate does not produce significant changes in the secondary structure of the proteins. The apo-Tf-Imt system is unstable under physiological conditions.