Utilizing direct skin feeding assays for development of vaccines that interrupt malaria transmission: A systematic review of methods and case study
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- 作者：Elizabeth B. Brickleya ; b ; c ; elizabeth.b.brickley@dartmouth.edu" class="auth_mail" title="E-mail the corresponding author ; Mamadou Coulibalyd ; doudou@icermali.org" class="auth_mail" title="E-mail the corresponding author ; Erin E. Gabriele ; erin.gabriel@nih.gov" class="auth_mail" title="E-mail the corresponding author ; Sara A. Healya ; sara.healy@nih.gov" class="auth_mail" title="E-mail the corresponding author ; Jen C.C. Humea ; jennifer.hume@nih.gov" class="auth_mail" title="E-mail the corresponding author ; Issaka Sagarad ; isagara@icermali.org" class="auth_mail" title="E-mail the corresponding author ; Sekou F. Traored ; cheick@icermali.org" class="auth_mail" title="E-mail the corresponding author ; Ogobara Doumbod ; okd@icermali.org" class="auth_mail" title="E-mail the corresponding author ; Patrick E. Duffya ; patrick.duffy@nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：Transmission-blocking vaccine ; Malaria ; Trial design ; Direct skin feed ; Vaccine activity
- 刊名：Vaccine
- 出版年：2016
- 出版时间：21 November 2016
- 年：2016
- 卷：34
- 期：48
- 页码：5863-5870
- 全文大小：526 K
文摘
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Vaccines that interrupt malaria transmission (VIMTs) suppress human infectivity.
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Direct skin feeding assays (DSFs) quantify transmission-blocking activity of VIMTs.
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DSFs are adaptable to heterogeneous settings, but methods require standardization.
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Statistical power is the key limitation for evaluating vaccine activity with DSFs.