Establishment of monoclonal antibodies against cell surface domains of ASCT2/SLC1A5 and their inhibition of glutamine-dependent tumor cell growth

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• 作者：Masayo Suzuki ; Hiroe Toki ; Akiko Furuya ; Hiroshi Ando ; ^{hiroshi.ando@kyowa-kirin.co.jp}
• 关键词：ASCT2 ; SLC1A5 ; Glutaminolysis ; Monoclonal antibody
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：651-657
• 全文大小：1792 K
• 卷排序：482

文摘

Antibodies recognizing alanine-serine-cysteine transporter 2 (ASCT2) were generated. KM4008, KM4012, and KM4018 antibodies were isolated through a cell-based screen. Isolated monoclonal antibodies inhibited glutamine-dependent cancer cell growth. Monoclonal antibodies against ASCT2 can be effective as anti-cancer therapy.