An integrative review of methylation at the serotonin transporter gene and its dialogue with environmental risk factors, psychopathology and 5-HTTLPR

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• 作者：H. Palma-Gudiel^a ; ^b ; ^c ; L. Fañ ; aná ; s^a ; ^b ; ^c ; ^{lfananas@ub.edu}
• 关键词：DNA methylation ; SLC6A4 gene ; 5-HTTLPR ; G  ; × ;   ; E interaction
• 刊名：Neuroscience & Biobehavioral Reviews
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：72
• 期：Complete
• 页码：190-209
• 全文大小：2067 K
• 卷排序：72

文摘

Exposure to both early and recent stress is associated with SLC6A4 hypermethylation. SLC6A4 hypermethylation is found in subjects suffering from psychiatric disorders. s carriers exposed to early stress are at higher odds of developing psychopathology. Several confounding factors have to be addressed in further analyses.