Repair of calvarial bone defects in mice using electrospun polystyrene scaffolds combined with β-TCP or gold nanoparticles

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• 作者：Lisa Terranova^a ; ^c ; Diana Maria Dragusin^d ; Romain Mallet^a ; ^b ; Eugeniu Vasile^e ; Izabela-Cristina Stancu^d ; Catherine Behets^c ; Daniel Chappard^a ; ^b ; ^{daniel.chappard@univ-angers.fr}
• 关键词：β-TCP ; beta tricalcium phosphate ; β-TCP-PS ; polystyrene scaffold blended with β-TCP ; AuNPs ; gold nanoparticles ; Au-PS ; polystyrene scaffold decorated with gold nanoparticles ; BAr/TAr ; bone area/total area ; DMF ; N ; N-dimethylformamide ; EDS ; energy X-ray dispersive spectroscopy ; FTIR ; fourier transform infrared spectroscopy ; hMSC ; human mesenchymal stem cells ; MicroCT ; X&ndash ; ray microcomputed tomography ; MSA ; mercaptosuccinic acid ; PS ; polystyrene ; SEM ; scanning electron microscopy ; UCL ; Universi
• 刊名：Micron
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：93
• 期：Complete
• 页码：29-37
• 全文大小：3609 K
• 卷排序：93

文摘

Development of polystyrene microfiber scaffolds, combined with beta-tricalcium phosphate grains or gold nanoparticles, by electrospinning. β-Tricalcium phosphate incorporated in the polystyrene scaffold enhanced in vitro cell proliferation compared to polystyrene alone scaffolds and gold-covered scaffolds. β-Tricalcium phosphate on polystyrene scaffold improved bone reconstruction in a model of critical size calvarial defect in mice.