G0/G1 Switch Gene 2 controls adipose triglyceride lipase activity and lipid metabolism in skeletal muscle
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- 作者：Claire Laurens1 ; 2 ; Pierre-Marie Badin1 ; 2 ; Katie Louche1 ; 2 ; Aline Mairal1 ; 2 ; Geneviè ; ve Tavernier1 ; 2 ; André ; Marette3 ; 5 ; Angelo Tremblay4 ; 5 ; S. John Weisnagel6 ; Denis R. Joanisse4 ; 5 ; Dominique Langin1 ; 2 ; 7 ; Virginie Bourlier1 ; 2 ; 8 ; Cedric Moro1 ; 2 ; 8 ; Cedric.Moro@inserm.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Lipid metabolism ; Skeletal muscle ; Lipolysis ; Adipose triglyceride lipase ; Oxidative metabolism
- 刊名：Molecular Metabolism
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：5
- 期：7
- 页码：527-537
- 全文大小：773 K
文摘
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G0S2 correlates with lipid content and oxidative capacity in skeletal muscle.
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ATGL activity is tightly controlled by basal expression of G0S2 in skeletal muscle.
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G0S2 controls lipid metabolism in a strictly ATGL-dependent manner in muscle.
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G0S2 regulates fuel selection through the transcriptional control of PDK4.