Neutralizing antibodies associated with exposure factors to Orthopoxvirus in laboratory workers

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• 作者：Galileu Barbosa Costa ; Elizabeth Castro Moreno ; Giliane de Souza Trindade ; Studies Group in Bovine Vaccinia
• 关键词：Vaccinia virus ; Occupational infection ; Serological survey
• 刊名：Vaccine
• 出版年：2013
• 出版时间：1 October, 2013
• 年：2013
• 卷：31
• 期：42
• 页码：4706-4709
• 全文大小：412 K

文摘

Extensive use of Vaccinia virus (VACV) in research has led to associated accidental human exposure in laboratories worldwide. In spite of the social and economic relevance of Bovine Vaccinia outbreaks in Brazil, national data concerning laboratory workers handling these infectious agents are relatively scarce. Therefore, a serological survey was conducted in a Brazilian laboratory to evaluate staff exposure to orthopoxviruses (OPVs). Information concerning direct work with OPVs, vaccination status and laboratory accidents was collected and correlated to serology results. This study presents an opportunity for discussion of routine procedures involving OPVs in laboratories and their intrinsic risks. Aspects of the live attenuated smallpox vaccine are also discussed.