Replication stalling and heteroduplex formation within CAG/CTG trinucleotide repeats by mismatch repair
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- 作者：David Viterboa ; b ; c ; Gré ; goire Michoudd ; Valentine Mosbacha ; b ; c ; Bernard Dujona ; b ; c ; Guy-Franck Richarda ; b ; c ; gfrichar@pasteur.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Replication pause ; Trinucleotide repeats ; Mismatch repair ; Heteroduplex
- 刊名：DNA Repair
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：42
- 期：Complete
- 页码：94-106
- 全文大小：2666 K
文摘
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CAG/CTG triplet repeats block replication in both orientations on a yeast chromosome.
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Replication fork stalling depends on mismatch repair integrity.
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Msh2p is enriched at CAG/CTG triplet repeats in both orientations.
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MSH2 overexpression favors or stabilizes the formation of heteroduplex molecules.