Mismatch repair enhances convergent transcription-induced cell death at trinucleotide repeats by activating ATR
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- 作者：Nimrat Chatterjeeb ; nimratchatterjee@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Yunfu Linc ; John H. Wilsona
- 关键词：Mismatch repair ; Convergent transcription ; ATR DNA damage response ; Trinucleotide repeat instability ; Neurodegenerative diseases ; Cell death
- 刊名：DNA Repair
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：42
- 期：Complete
- 页码：26-32
- 全文大小：1002 K
文摘
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Mismatch repair pathway enhance convergent transcription-induced cell death at CAG repeats.
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MutSβ and MutLα act in the same pathway to induce cell death during convergent transcription.
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MSH2, MSH3 and MLH1 activate ATR at CAG repeats during convergent transcription.