Proliferating cell nuclear antigen prevents trinucleotide repeat expansions by promoting repeat deletion and hairpin removal
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- 作者：Jill M. Beavera ; Yanhao Laib ; Shantell J. Rolleb ; Yuan Liua ; b ; c ; yualiu@fiu.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Proliferating cell nuclear antigen (PCNA) ; Base excision repair (BER) ; Trinucleotide repeats ; DNA repair ; DNA polymerase β (pol β) ; Flap endonuclease 1 (FEN1)
- 刊名：DNA Repair
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：48
- 期：Complete
- 页码：17-29
- 全文大小：3464 K
文摘
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PCNA was found to play a role in promoting TNR deletion and hairpin removal.
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PCNA stimulated the activity of FEN1 and pol β to remove a TNR hairpin during BER.
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PCNA stimulated LIG I to promote TNR deletions during BER in a TNR duplex.
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PCNA modulated the structure of dynamic DNA to facilitate BER in a TNR tract.