Nrf2 activation ameliorates cytotoxic effects of arsenic trioxide in acute promyelocytic leukemia cells through increased glutathione levels and arsenic efflux from cells
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- 作者：Shoichi Nishimotoa ; Toshihiro Suzukia ; Shin Koikea ; Bo Yuanb ; Norio Takagib ; Yuki Ogasawaraa ; yo@my-pharm.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Nrf2 ; Glutathione ; Arsenic trioxide ; Acute promyelocytic leukemia ; Carnosic acid
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：15 August 2016
- 年：2016
- 卷：305
- 期：Complete
- 页码：161-168
- 全文大小：982 K
文摘
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Nrf2 activation attenuates the effect of arsenic trioxide to acute promyelocytic leukemia cells.
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The sensitivity of arsenic trioxide to NB4 cells was dependent on efflux rate of arsenic.
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Activation of the GSH biosynthesis is essential in Nrf2-regulated responses for arsenic efflux.