Differential modulation of cellular antioxidant status in zebrafish liver and kidney exposed to low dose arsenic trioxide
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- 作者：Shuvasree Sarkara ; Sandip Mukherjeea ; Ansuman Chattopadhyayb ; Shelley Bhattacharyaa ; shelleyb38@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Arsenic trioxide ; Antioxidant genes ; Histopathology ; Kidney ; Liver ; Oxidative stress
- 刊名：Ecotoxicology and Environmental Safety
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：135
- 期：Complete
- 页码：173-182
- 全文大小：1894 K
文摘
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Differential response of As2O3 responsive antioxidant status in zebrafish.
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Antioxidant enzymes respond in a tissue-specific manner in liver and kidney.
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Oxidative damage was suppressed in liver at 90 days of As2O3 exposure.
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Longer exposure to As2O3 in kidney renders it more vulnerable than liver.
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Several stress-responsive genes were identified as molecular biomarkers of As2O3.