Arsenic trioxide mediates HAPI microglia inflammatory response and the secretion of inflammatory cytokine IL-6 via Akt/NF-κB signaling pathway

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• 作者：Gang Chen^a ; ¹ ; Jiamin Mao^a ; ¹ ; Jianmei Zhao^b ; Yan Zhang^c ; Ting Li^a ; Cheng Wang^c ; Lingfei Xu^a ; Qiaoyun Hu^a ; Xiaoke Wang^a ; Shengyang Jiang^a ; Xiaoke Nie^c ; Qiyun Wu^c ; ^{wqy@ntu.edu.cn}
• 关键词：Arsenic trioxide ; Microglia ; Akt/NF-кB/IL-6
• 刊名：Regulatory Toxicology and Pharmacology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：81
• 期：Complete
• 页码：480-488
• 全文大小：1388 K
• 卷排序：81

文摘

Arsenic trioxide exposure induced expression of IL-6 in HAPI microglia. AKT pathways were activated following Arsenic trioxide exposure in HAPI microglia. NF-κB pathways were activated following Arsenic trioxide exposure in HAPI microglia. The expression of IL-6 though AKT/NF-κB pathways in HAPI microglia.