Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72-ALS/FTD
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- 作者：Thomas Westergard1 ; Brigid K. Jensen1 ; Xinmei Wen1 ; Jingli Cai2 ; Elizabeth Kropf2 ; Lorraine Iacovitti2 ; Piera Pasinelli1 ; Davide Trotti1 ; 3 ; davide.trotti@jefferson.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：C9orf72 ; dipeptide repeat proteins ; DPR ; cell-to-cell transmission ; exosomes ; ALS ; FTD ; propagation
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：11 October 2016
- 年：2016
- 卷：17
- 期：3
- 页码：645-652
- 全文大小：2661 K
文摘
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Cell-to-cell transmission of DPRs is evident in vitro
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C9orf72-ALS patient-derived spinal motor neurons exhibit DPR transmission
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Exosomes containing DPRs are one modality for transmission
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Exosome-independent transmission is the primary mechanism for poly(PR) spread