Precipitation kinetics and biological properties of chitosan microparticles produced using supercritical assisted atomization
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- 作者：Hsien-Tsung Wu ; stwu@mail.mcut.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Hsiao-Kang Lee ; Hou-Cyuan Chen ; Liang-Jung Chien
- 关键词：Supercritical assisted atomization ; Sub-micrometric particles ; Chitosan ; Caco-2 cells ; Precipitation kinetics
- 刊名：Chemical Engineering Research and Design
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：104
- 期：Complete
- 页码：615-625
- 全文大小：2583 K
文摘
- •
Aqueous ethanol solution (50%, v/v) enhanced decompressive atomization efficiency.
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Effects of precipitation parameters on chitosan particles sizes were investigated.
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Mean particles size
could be correlated with the population balance model.- •
Chitosan particles reversibly opened epithelial tight junctions.
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Reversibility of the TEER changed depending on the viability of Caco-2 cells.