Composite particles formation for indomethacin-chitosan hydrochloride via an SAA.
Effects of size and CH/IMC mass ratio on drug dissolution rate were investigated.
SAA-treated IMC transformed from γ-form to the meta-stable α-form.
High CH/IMC mass ratio and micronized size could enhance IMC dissolution rate.
Enhanced permeability could be beneficial for the bioavailability of API.