Autopsy report on central pontine myelinolysis triggered by vomiting associated with digoxin intoxication
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- 作者：Kana Unuma ; Kazuki Harada ; Makoto Nakajima ; Hiromi Eguchi ; Kensuke Tsushima ; Takako Ito ; Kaori Shintani-Ishida ; Hideaki Kojima ; Ken-ichi Yoshida
- 关键词：Central pontine myelinolysis ; Digoxin ; Vomiting ; Autopsy
- 刊名：Forensic Science International
- 出版年：2010
- 出版时间：30 January 2010
- 年：2010
- 卷：194
- 期：1-3
- 页码：e5-e8
- 全文大小：294 K
文摘
An 87-year-old male, prescribed digoxin and furosemide for congestive heart failure and Alzheimer disease, had dehydration and anemia due to poor food intake and hemorrhagic cystitis. Repeated vomiting due to an upper respiratory infection caused disturbance of consciousness and hypotension. The patient was admitted to hospital and diagnosed with digoxin intoxication and hypernatremia. The serum sodium (Na+) level was corrected, but the patient died 4 days after admission following uncontrollable seizure. A histologic examination after an autopsy revealed characteristic findings of central pontine myelinolysis (CPM). This is the first autopsy report on CPM triggered by vomiting in association with digoxin administration.