文摘
Polymorphism A1/A2 in the β3 subunit of integrins αIIb/β3 and αV/β3 is implicated in the risk of development of embryonic and fetal recurrent pregnancy loss (RPL). In 191 women with RPL, polymorphism A1/A2 was statistically significantly associated with RPL at <10 weeks of gestation (29.3 % versus 16.4 % in controls), but it was much more pronounced in 67 women with RPL between 10 and 20 weeks of gestation (41.8 % ), illustrating its role in recurrent fetal loss.