Tuft Cells: New Players in Colitis

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• 作者：Shaun P. Steele¹ ; Stephanie J. Melchor¹ ; William A. Petri Jr¹ ; ^{wap3g@virginia.edu" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Trends in Molecular Medicine
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：22
• 期：11
• 页码：921-924
• 全文大小：1305 K

文摘

A recent surge of interest in tuft cells, which are chemosensory intestinal epithelial cells, has uncovered new functional roles for these cells in colorectal cancer, metabolic signaling, and type 2 immunity. Here, we explore emerging evidence suggesting that tuft cells are critical for protection during enteric infections and inflammatory responses.