Red cell superoxide dismutase activity in sporadic amyotrophic lateral sclerosis

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• 作者：Deniz Tuncel ; Nursel Aydin ; Pelin Aribal Kocatü ; rk ; Gü ; zin Ö ; zelç ; i Kavas ; Sevda Sarikaya
• 关键词：Amyotrophic lateral sclerosis ; Red cell superoxide dismutase ; Diagnosis ; Prognosis
• 刊名：Journal of Clinical Neuroscience
• 出版年：2006
• 出版时间：December 2006
• 年：2006
• 卷：13
• 期：10
• 页码：991-994
• 全文大小：110 K

文摘

Specific biologic markers are not available for definitive diagnosis and monitoring of disease progression in sporadic amyotrophic lateral sclerosis (SALS). Oxidative stress plays a role in ALS pathogenesis. The purpose of this study was to determine the association between Cu/Zn superoxide dismutase (SOD1) activity, diagnosis and prognosis. The present study included 25 SALS patients (SALS group; age 51 ± 12 years) and 10 healthy subjects (age 45 ± 5 years) as a control group. Patients were divided into groups representing four levels of diagnostic certainty of ALS in accordance with the El Escorial Revisited criteria. The disease state was determined using the modified ALS health state scale of Riviere et al. (Arch Neurol 1998:55;526–8). Red-cell SOD1 activity was determined by spectrophotometry. SOD1 activity in red cells was compared statistically with diagnostic criteria and disease state. Red cell SOD1 activity was high in all SALS patients, but there was no significant association between enzyme activity and diagnostic criteria and disease state. In this preliminary study, we did not find any correlation between SOD1 activity level and diagnosis or prognosis. Measured SOD1 activity sometimes supports ALS diagnosis, but it is neither a specific nor a prognostic factor.