Substrate-dependent cell elasticity measured by optical tweezers indentation
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- 作者：Muhammad S. Yousafzaia ; b ; Fatou Ndoyec ; d ; Giovanna Coceanoa ; b ; Joseph Niemelac ; Serena Bonine ; Giacinto Scolesf ; Dan Cojoca ; cojoc@iom.cnr.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cell elasticity ; Biomechanics ; Optical tweezers ; Elastic modulus ; Substrate stiffness
- 刊名：Optics and Lasers in Engineering
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：76
- 期：Complete
- 页码：27-33
- 全文大小：1975 K
文摘
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We propose a simple approach to locally measure cell elasticity by cell indentation.
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We applied pN forces at low loading rates in axial direction.
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Cell–bead interaction can be studied in all the three directions.
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We measured elastic modulus of HBL-100 cells.
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We demonstrated the cell壮s stiffness dependence on the substrate.