Revaccination does not improve an observed deficit in antibody responses in Pakistani adults born of a lower birth weight

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• 作者：Sophie E. Moore ; Fehmida Jalil ; Shousun Chen Szu ; Mirjana Hahn-Zoric ; Andrew M. Prentice ; Lars Å ; . Hanson
• 关键词：Vaccine responses ; Immune programming ; Birth weight
• 刊名：Vaccine
• 出版年：2008
• 出版时间：10 January 2008
• 年：2008
• 卷：26
• 期：2
• 页码：158-165
• 全文大小：346 K

文摘

We have previously shown that the generation of antibodies to a polysaccharide vaccine (Typhim Vi) is compromised in Pakistani adults born of a lower birth weight. To assess whether this represents a true B-cell-dependent deficit, we revaccinated subjects with a second dose of the same vaccine and with a polysaccharide–protein conjugate vaccine to a different polysaccharide antigen (conjugated Haemophilus influenzae type b (Hib) vaccine). Anti-Vi IgG levels remained positively correlated with birth weight (p = 0.0284) but no associations were observed between anti-Hib IgG levels and size at birth. These findings indicate that small size at birth results in a poor antibody response to vaccination with a polysaccharide antigen vaccine in adulthood, even following a second dose of the vaccine. No such association was observed in response to a polysaccharide–protein conjugate vaccine indicating an early-life programming effect on the generation of antibodies during a B-cell-dependent immune response.