UDCA and CDCA alleviate 17α-ethinylestradiol-induced cholestasis through PKA-AMPK pathways in rats
详细信息 查看全文
- 作者：Xiaojiaoyang Lia ; Zihang Yuana ; Runping Liuc ; Hozeifa M. Hassana ; e ; Hang Yanga ; Rong Sund ; Luyong Zhanga ; b ; lyzhang@cpu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Zhenzhou Jianga ; b ; beaglejiang@cpu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：PKA ; AMPK ; UDCA ; CDCA ; ICP
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2016
- 出版时间：15 November 2016
- 年：2016
- 卷：311
- 期：Complete
- 页码：12-25
- 全文大小：3000 K
文摘
- •
AMPK is involved in cholestatic liver injury with bile acid dysregulation.
- •
CDCA and UDCA inhibit the phosphorylation of AMPK and alleviate estrogen-induced cholestasis.
- •
PKA activation contributes to the CDCA- and UDCA-induced protective effects.
- •
FXR up-regulation may be critical for improvement of cholestasis.