Correlation between Total Solar Irradiance and Glycated Hemoglobin 2 to 3 Months Later in Patients with Diabetes: A Big-Data Analysis

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• 作者：Shigesumi Kinchiku ; MD^a ; ^{kinchiku_ukclabo@po14.synapse.ne.jp} ; Kazuhiko Kotani ; PhD MD^b ; Yukiko Maruguchi ; MD^a ; Anna Aikou ; MD^a ; Hitoshi Uenomachi ; MD^c ; Shouko Kajiya ; MD^c
• 关键词：A1C ; glycemic control ; insulin ; ultraviolet radiation ; weather
• 刊名：Canadian Journal of Diabetes
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：40
• 期：6
• 页码：543-547
• 全文大小：600 K
• 卷排序：40

文摘

Much attention has been paid recently to a relationship between glucose metabolism and weather. This study investigated the temporal correlation between total solar irradiance (TSI) and glycated hemoglobin (A1C) values in patients with diabetes.MethodsIn 1531 patients with diabetes who received follow-up care between 2009 and 2013 (type 1 diabetes, 123 patients; type 2 diabetes, 1408 patients; male 53.6%; mean age, 61.2 years), A1C levels were measured a total of 58,830 times. The correlation between mean monthly TSI and mean A1C values from 1 to 4 months later was then examined.ResultsThe mean values for TSI and A1C throughout the entire study period were 13.7 MJ/m2 and 7.7%, respectively. The correlation coefficient between TSI and mean monthly A1C values at 1 to 4 months was −0.516, −0.734, −0.726 and −0.475, respectively (all p<0.001).ConclusionsThere was a highly negative correlation between TSI and mean A1C values 2 to 3 months later in this population; thus, this fact may need to be considered when using A1C levels as a glycemic control index in patients with diabetes. Further studies are warranted.